Nano-titanium dioxide (TiO2 NPs), as a typical representative of nano-metal oxide material family, was first realized in commercial production, and has a wide application prospect in the fields of materials, energy, electronics, and bio-medicine. In recent years, nano-titanium dioxide has shown unique advantages in terms of contaminant enrichment, removal and detection due to its large specific surface area and high surface reactivity. With the increasing production and demand of nano-titanium dioxide, its environmental release behavior and potential interactions with contaminants have attracted attention. However, the interaction process between nano-TiO2 and pollutants is not yet clear, and its influence on the environmental behavior and bioavailability of pollutants and the mechanism of action remains to be further studied. Institute of Technology, Biology and Agro-Technology, Chinese Academy of Sciences, Xuan Group and Zhao Guoping's research group focus on trivalent arsenic, which is widely distributed and highly toxic in the environment, using human high-sensitivity gene mutation detection in human and mouse hybridoma mammals Cell (AL cell) models have made progress in elucidating the complex genotoxicity and mechanism of action of nano titanium dioxide and trivalent arsenic. The relevant research results were published in Nanotoxicology. Studies have shown that trivalent arsenic adheres to the nano-titanium dioxide aggregates by competing with the hydroxyl groups on the surface of the nano-titanium dioxide, thereby increasing the degree of agglomeration of the nano-titanium dioxide; at the same time, the presence of nano-titanium dioxide contributes to the incorporation of arsenic into the cells. Nano-titanium dioxide can significantly increase the genetic toxicity of arsenic-induced AL cells when it is non-toxic. Further research shows that the genetic toxicity of arsenic enhanced by nano-titanium dioxide is closely related to its arsenic-carrying pathway, and that mitochondria, as an important target organelle of pollutants, play a key role in mediating the arsenic genetic toxicity of nano-titanium dioxide. The study revealed the physical and chemical mechanisms of nano-titanium dioxide enhancing the genetic toxicity of trivalent arsenic and the response process at the cell level, providing a new experiment for the comprehensive assessment of potential environmental and health risks associated with the release of nano-titanium dioxide released into the environment and other pollutants. Based on and ideas. The research work was supported by the National Key Basic Research Development Program (973 Program), the Strategic Leading Science and Technology Project of the Chinese Academy of Sciences, the National Natural Science Foundation of China, and the Special Fund for the Dean of the Hefei Research Institute. Hmls Yarn,Tire Cord Polyester Yarn,Tire Cord Yarn Of Continental,Tire Cord Yarn Of Bridgestone ZHEJIANG GUXIANDAO POLYESTER DOPE DYED YARN CO., LTD , https://www.htpolyesteryarn.com
Nano-titanium dioxide enhances the mechanism of action of trivalent arsenic genetic toxicity